Daptomycin resistance in Enterococcus faecalis prosthetic valve endocarditis.
نویسندگان
چکیده
منابع مشابه
Treatment of high-level gentamicin-resistant Enterococcus faecalis endocarditis with daptomycin plus ceftaroline.
A recurrent case of left-sided endocarditis caused by high-level aminoglycoside-resistant Enterococcus faecalis was successfully treated with ceftaroline and daptomycin. This combination demonstrated excellent synergy in vitro. Mechanistically, ceftaroline enhanced binding of daptomycin to the cell membrane and sensitized E. faecalis to killing by human cathelicidin LL-37, a cationic innate hos...
متن کاملMitral valve endocarditis with high level aminoglycoside resistant Enterococcus faecalis in breast cancer patient
Introduction: Enterococci represent the third most common cause of infective endocarditis, after streptococcus and Staphylococcus aureus, and are responsible for 5–20% of all cases of endocarditis. We present a rare case of native valve Enterococcus faecalis (E. faecalis) endocarditis of mitral valve in a breast cancer patient. Case Report: A 56yearold breast cancer patient presented with com...
متن کاملEvaluation of the Enterococcus faecalis Biofilm-Associated Virulence Factors AhrC and Eep in Rat Foreign Body Osteomyelitis and In Vitro Biofilm-Associated Antimicrobial Resistance
Enterococcus faecalis can cause healthcare-associated biofilm infections, including those of orthopedic devices. Treatment of enterococcal prosthetic joint infection is difficult, in part, due to biofilm-associated antimicrobial resistance. We previously showed that the E. faecalis OG1RF genes ahrC and eep are in vitro biofilm determinants and virulence factors in animal models of endocarditis ...
متن کاملIn Vitro Activity of Daptomycin against Enterococcus faecalis under Various Conditions of Growth-Phases, Inoculum and pH
Enterococcus faecalis (E. faecalis) has become a major leading cause of nosocomial endocarditis. Treatment of such infections remains problematic and new therapeutic options are needed. Nine E. faecalis strains were tested: six obtained from patients presenting endocarditis, one with isolated bacteremia, and two reference strains. Antibiotics included daptomycin, alone or in combination, linezo...
متن کاملCombination therapy with ampicillin and daptomycin for treatment of Enterococcus faecalis endocarditis.
Enterococci are identified as the causative pathogen in approximately 10 percent of infective endocarditis cases, and the most frequently isolated species are Enterococcus faecalis and Enterococcus faecium (3). Gentamicin in combination with penicillins or glycopeptides is recommended for enterococcal endocarditis treatment; however, the incidence of ototoxicity and nephrotoxicity with aminogly...
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عنوان ژورنال:
- The Journal of antimicrobial chemotherapy
دوره 61 6 شماره
صفحات -
تاریخ انتشار 2008